FLOTUS
FLOTUS definition by Slang.net - The Slang Dictionary
This page explains what the acronym "FLOTUS" means. The definition, example, and related terms listed above have been manually compiled and written by the Slang.net team.
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An acronym that refers to the first lady, otherwise known as the wife of the President, of the United States; some notable women include Michelle Obama, Laura Bush, Nancy Reagan, and Hillary Clinton; similar to the POTUS acronym.