Handcuff
A fantasy football backup player
Example
I drafted Mckinnon as a handcuff to Peterson in case he gets hurt
Handcuff definition by Slang.net - The Slang Dictionary
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Handcuff is a fantasy football (FFB) term that describes a backup player that will replace the starter because of suspension, injury, or poor play. The position is usually a RB that will take over the majority of the carries if the starting RB gets injured.
Since football is a full contact sport injuries are inevitable in every game. Many players get injured every week, especially running backs, so FFB owners often draft one or two handcuffs as a safety net for when their running backs get hurt. This strategy is particularly effective when the handcuff plays on a run-heavy team, which means he'll get more chances to score points.